? Liquiritigenin (Licorice Flavanone) 98%

CAS: 578-86-9
Molecular Formula: C??H??O?
Molecular Weight: 256.25
Appearance: White crystalline powder

? Core Value Proposition

Selective Estrogen Receptor β (ERβ) Agonist & Anti-Inflammatory Agent

• ≥98% Purity (HPLC-verified, dual-method COA)

• Targeted Bioactivity: Binds ERβ with high affinity (EC?? = 36.5 nM for ERE tk-Luc activation) and suppresses pro-inflammatory mediators (TNF-α, IL-6, COX-2) 25.

• Neuro-Protective & Metabolic Benefits: Reduces neuroinflammation and enhances insulin sensitivity in preclinical models 36.

? Clinically Validated Benefits

1. Hormonal Balance & Breast Safety:

   • ERβ-Selective Action: Activates ERβ without stimulating uterine growth or breast cancer tumorigenesis (MCF-7 xenograft models) 25.

   • Osteoprotective: Prevents osteoblast apoptosis by inhibiting ROS and TNF-α in MC3T3-E1 cells 5.

2. Anti-Neuroinflammatory Effects:

   • Hippocampal Protection: Reduces IL-6, IL-1β, and TNF-α in serum and hippocampus by 40–60% in vivo, mitigating cognitive decline 56.

3. Antidiabetic Activity:

   • Glucose Regulation: Derivative Compound 10 (LTG-based) lowers blood glucose by 28% in diabetic models, outperforming isoliquiritigenin analogues 3.

4. Skin Barrier Repair:

   • Anti-Redness & Ceramide Boost: At 0.5–2.0%, accelerates eczema recovery via COX-2 inhibition (75%) and ceramide synthesis upregulation 6.

?? Technical Specifications

? Pharmaceutical & Cosmetic Applications

• Menopausal Health Supplements:
  Synergizes with phytoestrogens at 50–100 mg doses to alleviate hot flashes without uterine stimulation 25.

• Neuroprotective Formulations:
  In creams (1–3%) or nutraceuticals, combats hippocampal inflammation and oxidative stress 6.

• Anti-Acne Serums:
  At 0.5%, inhibits C. acnes-induced TLR2 activation and normalizes sebum (28% reduction) 6.

? Competitive Advantages

• Chromatographic Precision:
  Purified via high-speed counter-current chromatography (HSCCC), ensuring >98% purity and batch consistency 8.

• Enhanced Bioavailability:
  Cyclodextrin complexation boosts water solubility by 8× for toners and oral solutions 8.

• Global Compliance:
  Full dossiers for FDA GRAS, EU Cosmetic Regulation 1223/2009, and China IECIC.

? Packaging & Delivery

? FAQ

• How to verify ERβ agonist activity?
  Free in vitro assay report (ERE tk-Luc activation) with every batch.

• Compatible with retinoids?
  Yes—stabilizes retinol in pH 5.0–6.5 serums and enhances collagen synthesis.

• Stability in creams?
  Maintains >90% potency for 18 months in anhydrous bases.

? Why Partner With Us?

• Traceable Botanicals:
  Glycyrrhiza glabra from regenerative farms in Xinjiang (pesticide-free, soil-to-vial blockchain tracking).

• Custom Derivatives:
  Liquiritigenin Acetate (enhanced blood-brain barrier penetration) for neurological R&D.