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Pharmaceutical-Grade Curculigoside (≥98% Purity) | Natural Compound for Anti-Inflammatory & Bone Health Studies
Curculigoside is a high-purity phenolic glycoside isolated from Curculigo species, extensively utilized in pharmacological research for its potent bioactivities. With HPLC-confirmed purity ≥98%, this compound serves as a critical reference standard in drug discovery and mechanistic studies.
Product Name :
CurculigosideCAS No. :
85643-19-2Appearance :
White to off-white crystalline powderSpecification :
98%Molecular Formula: C??H??O?? | Molecular Weight: 466.44
Appearance: White to off-white crystalline powder
Source: Curculigo glabrescens (Orchidaceae family), sustainably harvested in China
? Pharma-Grade Purity & Bioactivity
Exclusively ≥98% Pure: Rigorously verified by HPLC-ELSD, NMR, and MS, with lot-specific Certificates of Analysis (COA).
Bioactivity Guaranteed: Confirmed multi-target modulation of JAK/STAT/NF-κB pathways, validated via cell-based assays for anti-osteoporotic, anti-arthritic, and neuroprotective efficacy.
? Clinically Validated Benefits
Anti-Osteoporotic Action: Significantly enhances bone mineral density by suppressing osteoclastogenesis via RANKL/OPG pathway modulation (in vivo models).
Anti-Arthritic Efficacy: Reduces joint inflammation and cartilage degradation by inhibiting JAK1/JAK3/STAT3 phosphorylation (IC??: 4–16 μg/ml in MH7A cells).
Neuroprotection: Attenuates oxidative stress and neuronal apoptosis in neurodegenerative models (e.g., Aβ-induced toxicity).
| Parameter | Detail |
|---|---|
| Purity | ≥98% (HPLC-ELSD) |
| Identification | NMR, Mass Spectrometry |
| Storage | 2–8°C, sealed, inert atmosphere, protected from light |
| Shelf Life | 24 months* |
| Solubility | DMSO (10 mM), methanol, ethanol; insoluble in water, chloroform, petroleum ether |
| Packaging | 20 mg–10 kg (vacuum-sealed vials or GMP-compliant drums) |
? Osteoporosis & Arthritis Therapeutics
Bone Health Adjuvant: Reverses glucocorticoid-induced bone loss by regulating Wnt/β-catenin and OPG/RANKL pathways.
Rheumatoid Arthritis Management: Suppresses synovial hyperplasia and cytokine storms (e.g., TNF-α, IL-6) via JAK/STAT inhibition.
? Neuroprotective & Anti-Inflammatory Research
Depression Therapy: Modulates hippocampal BDNF/TrkB signaling to exert antidepressant effects.
Neuroinflammation Control: Inhibits microglial activation and NF-κB-driven neurotoxicity in Parkinson’s/Alzheimer’s models.
| Advantage | Detail |
|---|---|
| Bioactivity Proof | Lot-specific JAK/STAT inhibition data included |
| Ethical Sourcing | Traceable to cultivated Curculigo glabrescens (China) |
| Global Compliance | ISO 9001, heavy metals ≤10 ppm (USP/EP standards), Kosher-certified |
| Weight | Packing Method | Transport |
|---|---|---|
| 20 mg–1 kg | Amber glass vials + desiccant + dry ice | DHL/FedEx (3–7 days) |
| 1 kg–25 kg | Sealed buckets with temperature loggers | By Air (5–10 days) |
| >25 kg | GMP drums (-20°C monitored) | By Sea (15–45 days) |
Q: How to validate anti-osteoporotic activity?
→ Free 20 mg samples provided with COA + in vitro osteoclastogenesis assay data.
Q: Solubility limitations for in vivo studies?
→ Cyclodextrin-complexed analogs available for enhanced aqueous solubility (OEM inquiries accepted).
Q: Stability during long-term storage?
→ Stability-tested for 24 months at 2–8°C; resealable packaging with nitrogen backfilling prevents oxidation.
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