What is the Cycloastragenol?

Cycloastragenol is Colorless needle crystal, while it's Molecular Formula is C30H50O5. Colorless needle crystal Cycloastragenol is an aglycone derivative of astragaloside IV found in the root of Korean Astragalus membranaceus.

What is the CAS number for Cycloastragenol?

The CAS number of Cycloastragenol is 84605-18-5.

What is Cycloastragenol (84605-18-5) used for?

Cycloastragenol (TA-65), a small-triterpenoid purified from the root of an Asian medicinal herb, has currently received particular attention for its potential to regulate transcription of telomerase. TA-65 is capable to increase average telomere length and to decrease the percentage of critically short telomeres and DNA damage in MEFs that harbor critically short telomeres. The effects on telomerase appear to be in common with other triterpenoid saponins (ie, ginsenosides RG1 and Rg3). These compounds at concentrations from 1 to 20 μM were reported to protect against IL-1β-, H2O2-, and tert-butylhydroperoxide-induced senescence in human chondrocytes, endothelial progenitor cells and fibroblasts, respectively.InChI:InChI=1/C30H50O5/c1-24(2)20(33)8-11-30-16-29(30)13-12-26(5)23(28(7)10-9-21(35-28)25(3,4)34)18(32)15-27(26,6)19(29)14-17(31)22(24)30/h17-23,31-34H,8-16H2,1-7H3/t17-,18-,19-,20-,21+,22?,23?,26+,27-,28-,29?,30?/m0/s1

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Conditions	Yield
Acidic conditions;

Conditions	Yield
With hydrogenchloride; In methanol; at 20 ℃; for 168h;	64%
With hydrogenchloride; In methanol; at 20 ℃; for 168h;	64%
With hydrogenchloride; In ethanol; benzene; for 24h; Heating;	30 mg
With sulfuric acid; In methanol; for 3h;	30 mg
Multi-step reaction with 2 steps 1: 47 mg / H₂SO₄ / methanol / 4 h / Heating 2: 17 mg / H₂SO₄ / methanol / 4 h / Heating With sulfuric acid; In methanol;
Multi-step reaction with 2 steps 1: 58 mg / H₂SO₄ / methanol / 4 h / Heating 2: 11 mg / H₂SO₄ / methanol; H₂O / 4 h / Heating With sulfuric acid; In methanol; water;
With water; Acidic conditions;
astragaloside IV; With sodium periodate; In methanol; water; at 20 ℃; With sodium tetrahydroborate; In methanol; at 20 ℃; for 24h; With sulfuric acid; In methanol; water; for 24h; pH=2;	384 mg
With hydrogenchloride; In methanol; chloroform; water; at 20 ℃; for 144h; Concentration;

Description	Cycloastragenol is a triterpenoid isolated from various legume species in the genus Astragalus that is purported to have telomerase activation activity. TA-65 is capable to increase average telomere length and to decrease the percentage of critically short telomeres and DNA damage in MEFs that harbor critically short telomeres. The effects on telomerase appear to be in common with other triterpenoid saponins (ie, ginsenosides RG1 and Rg3). These compounds at concentrations from 1 to 20 μM were reported to protect against IL-1β-, H2O2-, and tert-butylhydroperoxide-induced senescence in human chondrocytes, endothelial progenitor cells and fibroblasts, respectively.
Uses	Cycloastragenol is an aglycone derivative of astragaloside IV found in the root of Korean Astragalus membranaceus.
Definition	ChEBI: A sapogenin that is the aglycone derivative of astragaloside IV, a major saponin extracted from the root of Astragalus membranaceus.

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84605-18-5

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Cycloastragenol(Cas 84605-18-5) Usage

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84605-18-5 Process route

84605-18-5 Upstream products

84605-18-5 Downstream products

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